Wei Qin

Wei Qin developed TransitID, a novel proximity labeling technique targeting the spatial dynamic translocation of proteins. Using this method, he achieved the first mapping of protein trafficking between different organelles within cells and identified proteins transferred from cancer cells to macrophages via different pathways. This breakthrough fills the technological gap in the field of studying protein trafficking and provides a powerful tool for investigating dynamic processes, such as intercellular communication​.

Currently, Wei has founded a research group that is dedicated to in-depth studies in chemical biology, molecular probes, and spatiotemporal proteomics. His team is further developing multidimensional chemical proteomics techniques to explore important fundamental biological questions and discover novel molecular targets for major diseases. His long-term goal is to advance proteomics from one-dimensional to four-dimensional technology, enabling the depiction of the life trajectory of every protein in cells across the four dimensions of time, space, function, and interaction, thus precisely understanding the dynamic regulation of protein function​.

In the future, Wei plans to apply the developed technology to the field of tumor immunology, exploring different communication mechanisms between tumor cells and immune cells in the tumor microenvironment. This will provide new insights and approaches for the development of novel tumor immunotherapies​.